Yes. When you use Amazon’s Multi-Channel Fulfillment service to ship orders from other sales channels (like your Shopify store or eBay), you remain fully responsible for collecting and remitting sales tax on those non-Amazon orders.

Amazon only manages tax collection for sales made directly through the Amazon marketplace. For MCF orders, you’re responsible as if you were shipping them yourself – you must collect the appropriate sales tax at checkout and remit it to states. Amazon simply acts as your fulfillment center for these orders, not as the marketplace facilitator.